Selected Publications

Complete publication list

2024

Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome. JAMA Neurol (accompanying editorial)

2023

Transcobalamin Receptor Autoantibodies in Central Vitamin B12 Deficiency. medRxiv (preprint)

A predictive autoantibody signature in multiple sclerosis. medRxiv (preprint)

Detection of High-Risk Paraneoplastic Antibodies Against TRIM9 and TRIM67 proteins. Ann Neurol

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. Cell Rep Med (NIAID IMPACC Cohort)

Unbiased serology reveals autoimmunity and HIV antibody signatures in HIV CNS Escape. Journal of Neuroimmunology

Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report. Frontiers in Neurology

CAR-T Cell–Mediated B-Cell Depletion in Central Nervous System Autoimmunity. Neurology: Neuroimmunology and Neuroinflammation (collaboration with the Zamvil and Lim labs)

2022

Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin. Biological Psychiatry

Pathogen and antibody identification in children with encephalitis in Myanmar. Annals of Neurology

The Current Status of Next-Generation Sequencing for Diagnosis of Central Nervous System Infections. JAMA Neurology

βIV-Spectrin Autoantibodies in 2 Individuals With Neuropathy of Possible Paraneoplastic Origin. Neurology: Neuroimmunology and Neuroinflammation

Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics. Nature Communications

Multiple sclerosis therapies differentially impact SARS-CoV-2 vaccine-induced antibody and T cell immunity and function. JCI Insight (Collaboration with Sabatino, Zamvil and Bove labs)

2021

Anti–SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms. JAMA Neurology

Meningitis Caused by the Live Varicella Vaccine Virus: Metagenomic Next Generation Sequencing, Immunology Exome Sequencing and Cytokine Multiplex Profiling. Viruses

A false negative case of anti-Yo paraneoplastic myelopathy. Frontiers in Neurology

Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study. Science Immunology

Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid. JAMA Neurology

Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Cell Rep Med

2020

Gut microbiota–specific IgA+ B cells traffic to the CNS in active multiple sclerosis. Sci Immunol (collaboration with Baranzini lab)

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens. Cell Rep Med

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis. Proc Natl Acad Sci

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis. JAMA Neurology

Metagenomics for neurological infections — expanding our imagination. Nature Reviews Neurology

High resolution epitope mapping of anti-Hu and anti-Yo autoimmunity by programmable phage display. Brain Communications

Central Nervous System Virus Infection in African Children with Cerebral Malaria. Am J Trop Med Hyg

Genomic and serologic characterization of enterovirus A71 brainstem encephalitis. Neurology: Neuroimmunology and Neuroinflammation

Exploratory analysis of the potential for advanced diagnostic testing to reduce healthcare expenditures of patients hospitalized with meningitis or encephalitis. PLoS One

2019

Unbiased Metagenomic Sequencing for Pediatric Meningitis in Bangladesh Reveals Neuroinvasive Chikungunya Virus Outbreak and Other Unrealized Pathogens. mBio

Enteroviruses: the elephants in the room. Lancet Infectious Diseases

Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nature Medicine

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. New Engl J Med. (Accompanying Editorial)

Exploratory Proteomic Analysis Implicates the Alternative Complement Cascade in Primary CNS Vasculitis. Neurology

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis. New Engl J Med

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. PLoS ONE

Longitudinally persistent cerebrospinal fluid B-cells can resist treatment in multiple sclerosis. JCI Insight

2018

Clinicopathology Conference: 41 year old woman with chronic relapsing meningitis. Annals of Neurology

Whole-Genome mRNA Gene Expression Differs Between Patients With and Without Delirium. J Geriatr Psychiatry Neurol

Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. JAMA Neurol. (Accompanying Editorial)

Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. JAMA Neurol

Stroke incidence is highest in women and non-Hispanic Blacks living with HIV in the ALLRT cohort. AIDS

2017 and earlier

Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients. J Clin Invest Insight. 2017

A Novel Cause of Chronic Viral Meningoencephalitis: Cache Valley Virus. Ann Neurol. 2017

Emerging Diagnostic and Therapeutic Tools for Central Nervous System Infections. JAMA Neurol. 2016

Acute West Nile virus meningoencephalitis diagnosed via metagenomic deep sequencing of cerebrospinal fluid in a renal transplant patient. Am J Transplant. 2016

Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens. Genome Med. 2016

Multiplexed Metagenomic Deep Sequencing To Analyze the Composition of High-Priority Pathogen Reagents. mSystems. 2016

Depletion of Abundant Sequences by Hybridization (DASH): using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications. Genome Biol. 2016

Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing. Ann Neurol. 2015

Actionable diagnosis of neuroleptospirosis by next-generation sequencing. New Engl J Med. 2014